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#1040 TIM16 Inhibition Decreases Calcitonin Secretion and Enhances Sensitivity to Paclitaxel in a Human Medullary Thyroid Carcinoma Cells

Introduction: TIM 16 protein is part of the traslocase complex TIM 23 situated in the mitochondrial inner membrane, encoded by the Magmas gene, that is overexpressed in several tumors. Magmas silencing causes a greater sensitivity to apoptotic stimuli. We recently demonstrated that, in a human medullary thyroid carcinoma cell line (TT), compound 5, a TIM 16 inhibitor, was not cytotoxic but enhanced the proapoptotic effects of staurosporine

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Gagliano T, Riva E, Tagliati F, Matteotti D, Brugnoli V,

Keywords: TIM16, Magmas, Paclitaxel, Calcitonin, Medullary Thyroid Carcinoma,