Abstract Library

#3320 TGF-β increase caspase activation and migration in typical bronchial carcinoids

Introduction: Typical bronchial carcinoids (TBC) are well-differentiated neuroendocrine neoplasms (NEN) whose management can still be very challenging due to reduced sensitivity to therapy. Previous studies have reported TGF-β’s ability to activate mTOR pathway and induce epithelial to mesenchymal transition (EMT). Moreover, preliminary results show an overexpression of TGF-β signalling and caspase activation in TBC.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Gagliardi I

Authors: Borges de Souza P, Gagliardi I, Martelli M, Zatelli M,

Keywords: bronchial carcinoid, TGF-β signalling, mTOR, EMT,

#2690 Marked Response to Nab-Paclitaxel in Advanced Neuroendocrine Carcinoma of Nasal Sinuses: A Case Report

Introduction: Sinonasal neuroendocrine carcinomas (SNECs) are a very rare and high-grade malignant epithelial neoplasm that is usually associated with a poor prognosis.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Qi Z, Zhang Y, Li Y, Wang C, Wang X,

Keywords: neuroendocrine carcinoma, albumin-bound paclitaxe,

#1778 Chemotherapy for Pulmonary Large Cell Neuroendocrine Carcinomas: Does the Regimen Matter?

Introduction: Metastatic pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare disease and the most effective chemotherapy regimen is debated, i.e. small cell lung carcinoma (SCLC) or non-small cell lung carcinoma (NSCLC) chemotherapy.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Derks J

Authors: Derks J, Suylen R, Thunnissen E, Den Bakker M, Groen H,

Keywords: lcnec, chemotherapy, nec, lung,

#1294 The Efficacy and Safety of Sunitinib in Heavily Pretreated Patients with NETs. National Cancer Research Center Experience.

Introduction: There was done monocentral trial. 19 pts with progressive well differentiated NETs (G1,G2) were treated with sunitinib

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Odintsova A, Gorbunova V, Orel N, Markovich A, Kouzminov A,

Keywords: NET, sunitinib,efficacy,chemotherapy,

#1040 TIM16 Inhibition Decreases Calcitonin Secretion and Enhances Sensitivity to Paclitaxel in a Human Medullary Thyroid Carcinoma Cells

Introduction: TIM 16 protein is part of the traslocase complex TIM 23 situated in the mitochondrial inner membrane, encoded by the Magmas gene, that is overexpressed in several tumors. Magmas silencing causes a greater sensitivity to apoptotic stimuli. We recently demonstrated that, in a human medullary thyroid carcinoma cell line (TT), compound 5, a TIM 16 inhibitor, was not cytotoxic but enhanced the proapoptotic effects of staurosporine

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Gagliano T, Riva E, Tagliati F, Matteotti D, Brugnoli V,

Keywords: TIM16, Magmas, Paclitaxel, Calcitonin, Medullary Thyroid Carcinoma,