TGF-β increase caspase activation and migration in typical bronchial carcinoids


Introduction: Typical bronchial carcinoids (TBC) are well-differentiated neuroendocrine neoplasms (NEN) whose management can still be very challenging due to reduced sensitivity to therapy. Previous studies have reported TGF-β’s ability to activate mTOR pathway and induce epithelial to mesenchymal transition (EMT). Moreover, preliminary results show an overexpression of TGF-β signalling and caspase activation in TBC.

Aim(s): In order to understand the possible role for TGF-β signalling in TBC, and its crosstalk with mTOR, functional assays (cell viability, migration and caspase 3/7 activation) were performed in vitro in TBC cells.

Materials and methods: Cells were treated with the mTOR inhibitor everolimus (eve) and TGF-β alone or combined with controls IGF-1 and paclitaxel (pac).

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Gagliardi I

Authors: Borges de Souza P, Gagliardi I, Martelli M, Zatelli M,

Keywords: bronchial carcinoid, TGF-β signalling, mTOR, EMT,

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