Abstract Library

#4137 Liquid biopsy as a new tool for the molecular profiling of neuroendocrine neoplasms: The Gustave Roussy experience

Introduction: Molecular profiling (MP) in neuroendocrine neoplasm (NEN) tumor tissue may be useful for precision medicine. Liquid biopsy (LB) is an alternative noninvasive strategy to perform MP.

Conference:

Presenting Author:

Authors: Gagliardi I, Boilève A, Fodil-Cherif S, Moog S, Lamartina L,

Keywords: neuroendocrine tumor, neuroendocrine carcinoma, molecular profile, liquid biopsy, clonal hematopoiesis,

#4073 Comparative targeted NGS analysis between solid and liquid biopsies in GEP-NET: A pilot study

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present a broad clinical variability. Genetic profile could be a striking resource to respond to prognostic and treatment purposes. Sequencing of circulating tumor DNA (ctDNA) from liquid biopsy (LB) has been proposed as a less invasive alternative to solid biopsy (SB).

Conference:

Presenting Author:

Authors: Gagliardi I, Borges de Souza P, Martiradonna M, Rossi L, Albertelli M,

Keywords: Genetic profile, Liquid biopsy, Solid biopsy, GEP-NET, ctDNA,

#3812 Validation of NEP-D score as a prognostic index in bronchial carcinoid tumors

Introduction: The development of prognostic scores able to classify patients with Bronchial Carcinoid (BC) according to clinical outcomes may help guide treatment selection. The NEP- score was found to be useful to stratify survival probability in patients with well-differentiated neuroendocrine neoplasms (NENs). According to multiple factors (age, primary tumor site, presence of metastasis, Ki-67, presence of functioning status and prior surgical removal of the primary tumor) NEP- score stratifies patients into different risk groups. The NEP-score at diagnosis (NEP-D score) is a derived score that could be calculated at diagnosis and does not consider the appearance of new metastases during follow-up.

Conference:

Presenting Author:

Authors: Medici M, Gagliardi I, Zanata I, Borges de Souza P, Ambrosio M,

Keywords: Bronchial Carcinoid, Neuroendocrine neoplasm, NEP-Score, Prognosis, Survival,

#3320 TGF-β increase caspase activation and migration in typical bronchial carcinoids

Introduction: Typical bronchial carcinoids (TBC) are well-differentiated neuroendocrine neoplasms (NEN) whose management can still be very challenging due to reduced sensitivity to therapy. Previous studies have reported TGF-β’s ability to activate mTOR pathway and induce epithelial to mesenchymal transition (EMT). Moreover, preliminary results show an overexpression of TGF-β signalling and caspase activation in TBC.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Gagliardi I

Authors: Borges de Souza P, Gagliardi I, Martelli M, Zatelli M,

Keywords: bronchial carcinoid, TGF-β signalling, mTOR, EMT,