Comparative targeted NGS analysis between solid and liquid biopsies in GEP-NET: A pilot study

#4073

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present a broad clinical variability. Genetic profile could be a striking resource to respond to prognostic and treatment purposes. Sequencing of circulating tumor DNA (ctDNA) from liquid biopsy (LB) has been proposed as a less invasive alternative to solid biopsy (SB).

Aim(s): Verify the reliability of the mutational profile (MP) provided by LB compared to SB sequencing.

Materials and methods: SB and LB were derived simultaneously from 6 GEP-NET patients (pts), and DNA was extracted. A comparative targeted NGS analysis was performed to evaluate the mutational status of 11 genes (MEN1, DAXX, ATRX, MUTYH, SETD2, DEPDC5, TSC2, ARID1A, CHECK2, MTOR, PTEN).

Conference:

Presenting Author:

Authors: Gagliardi I, Borges de Souza P, Martiradonna M, Rossi L, Albertelli M,

Keywords: Genetic profile, Liquid biopsy, Solid biopsy, GEP-NET, ctDNA,