Abstract Library
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#4073 Comparative targeted NGS analysis between solid and liquid biopsies in GEP-NET: A pilot study
Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present a broad clinical variability. Genetic profile could be a striking resource to respond to prognostic and treatment purposes. Sequencing of circulating tumor DNA (ctDNA) from liquid biopsy (LB) has been proposed as a less invasive alternative to solid biopsy (SB).
Conference:
Presenting Author:
Authors: Gagliardi I, Borges de Souza P, Martiradonna M, Rossi L, Albertelli M,
Keywords: Genetic profile, Liquid biopsy, Solid biopsy, GEP-NET, ctDNA,
Introduction: Patients with sporadic gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN) may exhibit a higher risk of second primary tumors than the general population.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Massironi S
Authors: Massironi S, Campana D, Pusceddu S, Albertelli M, Faggiano A,
Keywords: GEP-NEN, Second primary neoplasm (PMN), Overall survival (OS),
Introduction: To date no systematic prospective trials have been carried out to evaluate safety and efficacy of unconventional doses of somatostatin analogs (SSAs) in neuroendocrine tumors (NETs). However,dose escalation of SSAs is a common strategy.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Authors: Albertelli M, Campana D, Faggiano A, Spada F, Baldelli R,
Keywords: SSA high dose,
Introduction: Somatostatin analogues (SSAs) are the cornerstone of systemic therapy for well-differentiated GEPNETs. Dose escalation of SSAs is often trialled in clinical practice, but small studies have yielded mixed results.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Authors: Chan D, Ferone D, Segelov E, Albertelli M, Singh S,
Keywords: Escalated dose, octreotide, lanreotide, SSA,
Introduction: Dose escalation (or interval reduction) of somatostatin analogs (SSAs) is a rather common strategy for patients (pts) with progressive metastatic neuroendocrine tumors (NETs). However, to date, no systematic prospective studies have been carried out to evaluate safety and efficacy of this treatment schedule in NETs.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author:
Authors: Albertelli M, Campana D, Faggiano A, Spada F, Baldelli R,
Keywords: high doses lanreotide safety ,