Abstract Library
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ENETS Abstract Search
Introduction: Specific components of ghrelin-system are associated with tumor development/ progression. We have previously described the presence of this system in neuroendocrine tumors (NETs) but clinical-molecular correlations have not been elucidated yet.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Herrera-Martinez A
Authors: Herrera-Martínez A, Gahete M, Sánchez-Sánchez R, Ortega Salas R, Serrano R,
Keywords: GEP-NET, ghrelin system, GOAT, GHSR1a, prognosis, invasion,
#1875 Potential Anti-Tumor Activity of Biguanides and Statins in Neuroendocrine Tumor Cells
Introduction: Recent studies have suggested that biguanides and statins have beneficial effects on various cancer types; however, the precise effects and the molecular mechanisms underlying this pathophysiological association are still not well understood in neuroendocrine tumor (NETs).
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Authors: Herrera-Martínez A, Pedraza-Arévalo S, López-López F, Gahete M, Gálvez-Moreno M,
Keywords: NETs,biguanides,statins,
Introduction: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cell. The only available treatment is surgical resection, which is not always feasible. Somatostatin and its receptors are expressed both in normal human thyroid C cells and in MTC, but their role has not been fully elucidated. The discovery of a truncated isoform of Sstr5, Sstr5TMD4, associated with increased invasiveness and aggressiveness in breast cancer, has opened new insight in the role of Sstr in cancers.
Conference: 11th Annual ENETSConcerence (2014)
Presenting Author: Zatelli M
Authors: Molè D, Gahete M, Gagliano T, Tagliati F, Castano J,