Abstract Library

Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.

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#2116 Ghrelin O-Acyltransferase (GOAT) Enzyme and Ghrelin Receptor GHSR1a as Putative Prognosis Markers and Therapeutic Targets in Gastroenteropancreatic Neuroendocrine Tumors

Introduction: Specific components of ghrelin-system are associated with tumor development/ progression. We have previously described the presence of this system in neuroendocrine tumors (NETs) but clinical-molecular correlations have not been elucidated yet.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Herrera-Martinez A

Authors: Herrera-Martínez A, Gahete M, Sánchez-Sánchez R, Ortega Salas R, Serrano R,

Keywords: GEP-NET, ghrelin system, GOAT, GHSR1a, prognosis, invasion,

#1875 Potential Anti-Tumor Activity of Biguanides and Statins in Neuroendocrine Tumor Cells

Introduction: Recent studies have suggested that biguanides and statins have beneficial effects on various cancer types; however, the precise effects and the molecular mechanisms underlying this pathophysiological association are still not well understood in neuroendocrine tumor (NETs).

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Herrera-Martínez A, Pedraza-Arévalo S, López-López F, Gahete M, Gálvez-Moreno M,

Keywords: NETs,biguanides,statins,

#986 Expression of the Truncated Somatostatin Receptor Variant Sstr5TMD4 in Medullary Thyroid Carcinoma

Introduction: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cell. The only available treatment is surgical resection, which is not always feasible. Somatostatin and its receptors are expressed both in normal human thyroid C cells and in MTC, but their role has not been fully elucidated. The discovery of a truncated isoform of Sstr5, Sstr5TMD4, associated with increased invasiveness and aggressiveness in breast cancer, has opened new insight in the role of Sstr in cancers.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Zatelli M

Authors: Molè D, Gahete M, Gagliano T, Tagliati F, Castano J,

Keywords: MTC, SSTR5TMD4,