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Introduction: Specific components of ghrelin-system are associated with tumor development/ progression. We have previously described the presence of this system in neuroendocrine tumors (NETs) but clinical-molecular correlations have not been elucidated yet.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Herrera-Martinez A
Authors: Herrera-Martínez A, Gahete M, Sánchez-Sánchez R, Ortega Salas R, Serrano R,
Keywords: GEP-NET, ghrelin system, GOAT, GHSR1a, prognosis, invasion,
Introduction: Splicing is an emerging cancer hallmark influencing multiple tumor cell (dys)functions. We have shown that aberrantly spliced variants of somatostatin receptor subtype 5 (sst5TMD4) and of the pleiotropic neuropeptide ghrelin (in1ghrelin) are linked to poor prognosis in gastroenteropancreatic neuroendocrine tumors (GEPNETs) and may enhance their aggressiveness features.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Castaño J
Authors: Castaño J, Pedraza-Arevalo S, Herrea-Martinez A, Del Río-Moreno M, Sánchez-Sánchez R,
Keywords: Splicing,
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