Abstract Library

#850 Expression of IGF/mTOR Pathway Components in Human Pheochromocytomas and In Vitro Inhibition of PC12 rat Pheochromocytoma Cell Growth by mTOR Inhibitors alone and in Combination with the Dual IGFI-R/INS-R Antagonist OSI-906

Introduction: Dysregulation of the mTOR and IGF pathways have been suggested to be involved in the pathogenesis of pheochromocytomas (PCC). mTOR inhibitors, such as sirolimus (S) and everolimus (E), as well as IGFI-R antagonists such as OSI-906, could be new a treatment for malignant PPC.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: De Martino M

Authors: De Martino M, Feelders R, Dogan F, Van Koetsveld P, De Krijger R,

Keywords: IGF, mTOR, everolimus, OSI-906, pheochromocytoma, PC12, adrenal, neuroendocrine, tumor,

#269 Expression of IGF/mTOR Pathway Components in Human Pheochromocytomas and In Vitro Inhibition of PC12 Rat Pheochromocytoma Cell Growth by mTOR Inhibitors

Introduction: The pathogenesis of pheochromocytomas (pheo) is poorly understood and malignant pheo need new treatment options. mTOR inhibitors, as sirolimus(S) and everolimus(E), are promising antineoplastic drugs.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: De Martino M, Feelders R, van Koetsveld P, De Krijger R, Sprij-Mooij D,

Keywords: IGF, mTOR, everolimus, sirolimus, pheochromocytomas, PC12, adrenal, neuroendocrine, tumor,