Well Differentiated Pancreatic Neuroendocrine Tumors (WDPNET) G3: Does the Ki67 Really Do It All? Abstract #1564

Introduction: WDPNET G3, although not recognized by the 2010 WHO classification are far from exceptional. They also represent a great therapeutic challenge especially since their molecular drivers are unknown.
Aim(s): Compare the transcriptomic profiles of aggressive WDPNET with those of less proliferative WDPNET and of poorly differentiated neuroendocrine carcinomas (NEC) to identify driver oncogenic pathways.
Materials and methods: Two pathologists determined differentiation and hand counted the ki67 of 29 PNET. Transcriptomic profiles were obtained with Affymetrix HTA 2.0 chips. Among the 26 WDPNET, 7 tumors had a Ki67 below 5%, 5 between 5-15% and 14 between 17-39%. 3 NEC had a Ki67 between 47-95%.
Conference: 13th Annual ENETS conference (2016)
Category: Basic Science - Genetics, epigenetics, miRNAs
Presenting Author: Dr Jerome Cros

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