Abstract Library

#3989 Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Introduction: Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare. Hypoxia and lipid metabolism-related gene acetyl-CoA synthetase 2 (ACSS2) is involved in tumor progression, but its role in pNENs is not revealed.

Conference:

Presenting Author:

Authors: Gu D, Ye M, Zhu G, Bai J, Tang Q,

Keywords: hypoxia, ACSS2, lipid metabolism reprogramming, HMGCS1, PI3K/AKT/mTOR pathway, pancreatic neuroendocrine neoplasm,

#876 Incidence and Prevalence of Neuroendocrine Tumors (NETs) of the Ileum and Colon (Excluding Appendiceal NETs) in Northern Ireland (NI) Over a 25-Year-Period (1988-2012)

Introduction: Incidence of NETs is quoted to be 2/100,000 with approximately 25% being tumors of the midgut, (0.5/100,000). Incidence is increasing. However, this may be in part due to improved diagnosis but it is also thought to be a true increase.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Ardill J

Authors: Ardill J, Johnston B, Stronge W, Turner G, McCance D,

Keywords: MGC,

#669 Incidence of Second Malignancy in Patients with Neuroendocrine Tumors (NETs) of the Ileum and Colon (MGC)

Introduction: Increased incidence of second malignancy is observed in NETs (Kamp et al 2012).

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Ardill J

Authors: Ardill J, Johnston B, Stronge W, Turner G, McCance D,

Keywords: second malignancy, MGC,colon cancer,

#509 Activation of EGFR and c-Met Signaling Pathways in Well-Differentiated Neuroendocrine Tumors of the Small Intestine

Introduction: The biological mechanisms driving midgut carcinoid (MGC) are unknown. The purpose of this study is to explore the role of EGFR and c-Met signaling pathways in the pathogenesis.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Liu E, Mikhitarian K, Revetta F, Shi C,

Keywords: carcinoid, EGFR, c-met, immunohistochemistry,

#508 Differential Expression of Markers in a Midgut Carcinoid Tissue Microarray

Introduction: Molecular mechanisms driving well-differentiated midgut carcinoid (MGC) tumors are not well-established. To pursue higher resolution tumor diagnostics, we studied a panel of markers for their expression in MGC, including: serotonin, FGF2, b-catenin, and E-cadherin, in primary, lymph node, and liver metastases.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Liu E, Mikhitarian K, Revetta F, Shi C,

Keywords: midgut carcinoid, immunohistochemistry, markers,