Abstract Library

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#2068 Durvalumab plus Tremelimumab for the Treatment of Patients (pts) with Advanced Neuroendocrine Neoplasms (NENs) of Lung or Gastroenteropancreatic (GEP) Origin. A Phase II Multicohort Trial (DUNE Trial / GETNE 1601)

Introduction: Immuno check-point inhibitors development in grade 1-2 NENs is limited by low mutation tumor load and PD-1/PDL-1 expression. The combination of an PDL-1 and CTLA-4 inhibitors could increase the probability of success in this setting. In high grade NENs the rational for immunotherapy is stronger based on experiences in small cell lung cancer.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Hernando-Cubero J

Authors: Hernando-Cubero J, Manzano J, Benavent M, Lopez C, Teulé R,

Keywords: Durvalumab, Tremelimumab, Neuroendocrine, Immunotherapy,

#2024 Metachronous Primary Cancers in Neuroendocrine Tumor Patients

Introduction: Historically there has been an association between neuroendocrine tumours (NETs) and second primary cancers (Stronge et al 2014). However, this has not been well characterised.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Genus T

Authors: Genus T, Bouvier C, Wong K, Srirajaskanthan R, Rous B,

Keywords: Neuroendocrine cancer, second primary, metachronous,

#876 Incidence and Prevalence of Neuroendocrine Tumors (NETs) of the Ileum and Colon (Excluding Appendiceal NETs) in Northern Ireland (NI) Over a 25-Year-Period (1988-2012)

Introduction: Incidence of NETs is quoted to be 2/100,000 with approximately 25% being tumors of the midgut, (0.5/100,000). Incidence is increasing. However, this may be in part due to improved diagnosis but it is also thought to be a true increase.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Ardill J

Authors: Ardill J, Johnston B, Stronge W, Turner G, McCance D,

Keywords: MGC,

#669 Incidence of Second Malignancy in Patients with Neuroendocrine Tumors (NETs) of the Ileum and Colon (MGC)

Introduction: Increased incidence of second malignancy is observed in NETs (Kamp et al 2012).

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Ardill J

Authors: Ardill J, Johnston B, Stronge W, Turner G, McCance D,

Keywords: second malignancy, MGC,colon cancer,