Cell-free DNA concentration correlates with copy number variant (CNV)-count, describes tumour progression and nuclear instability in GEP-NETs

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Introduction: Cell-free DNA (cfDNA) levels depend on various factors related to the shedding of cells and might provide valuable information on tumour state and treatment success. In a genomic profiling pilot study conducted as part of the COMPOSE Phase III multicentre open-labelled clinical trial we assessed multiple factors and their impact on cfDNA levels in 14 GEP-NET patients.

Aim(s): We were seeking to identify the strongest determinants of cfDNA levels to determine the minimal sample quantities needed for conclusive assessment of liquid biopsies. We further explored underlying reasons, influencing factors and correlating clinical and genomic data.

Materials and methods: Longitudinally sampled liquid biopsies of 14 GEP-NET patients participating in the pilot study were assessed for cfDNA levels and compared against potential contributing factors in a multivariate statistic model.

Conference:

Presenting Author: Srirajaskanthan R

Authors: Srirajaskanthan R, Capdevila J, Smutna V, Weckwerth W, Erdoe M,

Keywords: CNV, cfDNA, liquid biopsy, quantitative marker, cfDNA concentration, longitudinal, GEP-NET, genomic profiling,