#3963
Infrastructure FOr Rare Cancer in the NEtherlands, towards a comprehensive platform for early detection and diagnosis of rare cancers (FORCE), and especially neuroendocrine neoplasms (NEN)
Introduction:
NEN consist of a heterogeneous group of rare tumors. For these patients, clinical trials requiring a high number of patients are often infeasible. Often, the prognosis is poor due to late diagnosis and fewer available treatment options as compared to patients with common cancer types. In common cancers, ultrasensitive molecular profiling of circulating cell-free DNA (USccfDNA) based tests are promising to improve diagnosis, detection of minimal residual disease (MRD), and recurrence. Data needed to apply USccfDNA in NEN is lacking.
Conference:
Presenting Author:
Authors:
de Hosson L,
Pieterman C,
Fehrmann R,
de Herder W,
Jalving M,
Keywords:
circulating cell free DNA,
biobank,
databank,
early detection,
#1465
Assocation Between miRNAs and HDACs in Pancreatic Neuroendocrine Tumors
Introduction:
Epigenetic factors are essentially involved in carcinogenesis, tumor promotion and chemo resistance with their major key players of miRNAs and histone deacetylases (HDACs). As shown by own theoretical databank analysis, the crosstalk between miRNAs and HDACs are relevant in different human chronic diseases and cancerogenic pathways.
Conference:
13th Annual ENETSConcerence (2016)
Presenting Author:
Authors:
Swierczynski S,
Klieser E,
Urbas R,
Stättner S,
Primavesi F,
Keywords:
Epigenetics,
miRNA,
histone deacetylases,
pancreatic neuroendocrine tumor,
#36
A monocentric analysis of patients with pulmonary neuroendocrine tumors over 15 years: long term survival and life quality dependent from histological subtypes and surgical management
Introduction:
Pulmonary neuroendocrine tumors substantially differ from epithelial tumors in terms of tumor biology and prognosis. In specialized interdisciplinary centers, a broad therapeutical armentarium can be used to achieve optimal treatment.
Conference:
7th Annual ENETSConcerence (2010)
Presenting Author:
Authors:
Zahn S,
Hornung H,
Schick K,
Winter H,
Jauch K,
Keywords:
surgical therapy,
pulmonary neuroendocrine tumors,
typical carcinoid,
atypical carcinoid,
long-term experience,
survival.,
