Abstract Library
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Introduction: Recent studies have shown that Pancreatic neuroendocrine carcinomas (NECs) contain well-differentiated NETs with high proliferative activity (WDNET-G3), as well as poorly differentiated NECs (PDNECs). Although patients with pNEC show variable responses to platinum-based chemotherapy, predictors of the response are unknown.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Hijioka S
Authors: Hijioka S, Hosoda W, Matsuo k, Ueno M, Furukawa M,
Introduction: Recent studies have shown that Pancreatic neuroendocrine carcinomas (NECs) contain well-differentiated NETs with high proliferative activity (WDNET-G3), as well as poorly differentiated NECs (PDNECs). Although patients with pNEC show variable responses to platinum-based chemotherapy, predictors of the response are unknown.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Hijioka S
Authors: Hijioka S,
Introduction: Although much progress has been made in the past 2-3 years in terms of understanding signaling pathways in gastroenteropancreatic neuroendocrine tumors (GEP-NENs), approved treatment options are still limited. Cancer Immunotherapy has been announced as the breakthrough of the year in 2013 and might become an integral part of the clinical management strategy for solid tumors including GEP-NENs. Therefore, to develop immunotherapeutic strategies against NENs we need to know which immune escape mechanisms are relevant in high and low grade NEC/NENs.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author: Grabowski P
Authors: Grabowski P, Joehrens K, Arsenic R, Kaemmerer D, Hummel M,
Keywords: Immunophenotype, PD-L1, poorly differentiated NECs, immunotherapy,