Abstract Library

#2275 Analysis of Gene Expression Patterns of Rectum Neuroendocrine Tumors (NET) Versus Healthy Tissue Reveals Alterations in the MAPK and WNT Signaling Pathways

Introduction: The neuroendocrine tumors (NETs) of the rectum are rare but increasing in incidence, by means of improved endoscopic techniques and histological reporting. They often occur as small polypoid lesions and G1, and in most cases an incidental finding at endoscopy.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Briest F

Authors: Briest F, Hummel M, Grabowski P, Arsenic R,

Keywords: rectum neuroendocrine tumors, NET, MAP kinase, gene expression analysis, Wnt signaling,

#1577 Peritoneal Carcinomatosis in Digestive Neuroendocrine Neoplasms: Complications and Response to Therapy

Introduction: Peritoneal carcinomatosis (PC) is present in 10-30% of digestive neuroendocrine neoplasms (DNENs), affecting prognosis and quality of life with recurrent abdominal pain and bowel obstruction

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: merola e

Authors: Merola E, Prasad V, Pascher A, Denecke T, Arsenic R,

Keywords: peritoneal carcinomatosis, neuroendocrine, bowel obstruction,

#1474 Curative Resection in Digestive Neuroendocrine Neoplasms: Recurrence-free Survival Rate and Definition of a Risk Score for Recurrence

Introduction: Surgery with radical intent is the only curative option for digestive neuroendocrine neoplasms (DNENs), but clinical practice shows disease-free pts recurring even after years

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Merola E, Pascher A, Denecke T, Arsenic R, Wiedenmann B,

Keywords: neuroendocrine, curative surgery, recurrence risk,

#1347 Evaluation of the Somatostatin, CXCR4 Chemokine and Endothelin A Receptor Expression in a Large Series of Paragangliomas

Introduction: Paragangliomas are predominantly benign tumors, but in some cases invasive growth and also metastasis is observed. Given the limited number of nonsurgical treatment options, novel target structures for diagnostics and therapy of this tumor entity are urgently needed.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Kaemmerer D

Authors: Kaemmerer D, Sänger J, Arsenic R, D'Haese J, Neumann J,

Keywords: paraganglioma, somatostatin, CXCR4,

#1199 Tumor Infiltrating Lymphocytes and PD-L1 Expression Differ in Low and High Grade Neuroendocrine Tumors

Introduction: Although much progress has been made in the past 2-3 years in terms of understanding signaling pathways in gastroenteropancreatic neuroendocrine tumors (GEP-NENs), approved treatment options are still limited. Cancer Immunotherapy has been announced as the breakthrough of the year in 2013 and might become an integral part of the clinical management strategy for solid tumors including GEP-NENs. Therefore, to develop immunotherapeutic strategies against NENs we need to know which immune escape mechanisms are relevant in high and low grade NEC/NENs.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Grabowski P

Authors: Grabowski P, Joehrens K, Arsenic R, Kaemmerer D, Hummel M,

Keywords: Immunophenotype, PD-L1, poorly differentiated NECs, immunotherapy,