Comparative Marker Assessment in Small Cell Lung Cancer with Good and Poor Prognosis

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Introduction: Small cell lung cancers (SCLC) are highly aggressive and poorly differentiated neuroendocrine neoplasms which comprise ̴̴̴15 % of all lung malignancies.

Aim(s): In a panel of patients with diagnosed SCLC with poor and good prognosis we investigated the prognostic impact by analyzing protein and mRNA expression levels of 9 molecular markers. Furthermore we studied the influence of therapeutic interventions on the prognosis.

Materials and methods: Formalin-fixed, paraffin-embedded tumor samples of 27 SCLC patients with good prognosis (survival ≥ 30 months) and 19 patients with poor prognosis (survival < 30 months) were analyzed for the receptors SSTR1, 2A, 3, 4, 5, CXCR4 and the proliferation markers Ki-67, TOP2A and RacGAP1 by means of immunohistochemistry and RT-qPCR.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Schmidt L, Specht E, Reimann C, Kaemmerer D, Wirtz R,

Keywords: SCLC, SSTR, CXCR4, proliferation,