#4615
Dosimetry, efficacy and safety of radiolabelled somatostatin receptor antagonist in patients with metastatic pheochromocytoma or paraganglioma
Introduction:
Metastatic pheochromocytomas and paragangliomas (mPPGLs) are rare neuroendocrine tumours with a heterogenous phenotype and a variable treatment response. The SSTR antagonist [177Lu]Lu177Lu-DOTA-JR11 (177Lu-JR11) offers potentially increased tumour doses than standard radioligand therapy (RLT) with [177Lu]Lu-DOTA-TOC (177Lu-TOC).
Conference:
Presenting Author:
Lider S
Authors:
Lider Burciulescu S,
Schmidt F,
McDougall L,
Bernhardt P,
Mushaweh A,
Keywords:
Metastatic PPGL,
radioligand therapy,
somatostatin receptor antagonist,
dosimetry,
#3553
Gamma-glutamyltransferase as an indicator of hepatic tumor burden in neuroendocrine tumors
Introduction:
In patients with neuroendocrine tumors (NETs) and liver metastasis, elevation of gamma-glutamyltransferase (GGT) is considered to be a sign of hepatic progression. However, there are no data supporting this assumption.
Conference:
Presenting Author:
Schmidt B
Authors:
Schmidt B,
Leiderer M,
Amin T,
Viol F,
Adam G,
Keywords:
gamma glutamyltransferase,
hepatic tumor burden,
neuroendocrine tumor,
liver metastasis,
biomarker,
#69
Frequent biological association of Merkel cell polyomavirus with Merkel cell carcinomas
Introduction:
Merkel cell polyomavirus (MCPyV) DNA has been detected by PCR in 75–100% of Merkel cell carcinomas (MCC), an aggressive neuroendocrine skin cancer. MCPyV is a 5.4 kb DNA virus that expresses tumor (T) antigen in tumor tissues.
Conference:
7th Annual ENETSConcerence (2010)
Presenting Author:
Speel E
Authors:
Speel E,
Schmidt A,
Baumann M,
Haesevoets A,
Diebold J,
Keywords:
Merkel cell polyoma virus,
Merkel cell carcinoma,
neuroendocrine skin cancer,
FISH,
large T antigen,
