Genetic Analysis Identifies Subgroups of Small Well-Differentiated Pancreatic Neuroendocrine Tumors with Different Risk for Liver Metastases Abstract #2093

Introduction: Small size well-differentiated pancreatic neuroendocrine tumors (PanNETs) behave non-aggressively. However, a limited subset progresses with liver metastases.
Aim(s): This study aimed to investigate molecular alterations associated with metastasis.
Materials and methods: 87 primary PanNETs <3cm, including 32 metastasizing to liver and 55 non-metastatic after a 5-year follow-up were immunostained for DAXX and ATRX and analyzed for alternative lengthening of telomeres (ALT) by fluorescent in situ hybridization. A subset of 48 cases, 24 metastasizing and 24 non-metastasizing were subjected to mutational analysis of 18 genes by targeted next-generation sequencing and to whole-genome copy number variation (CNV) analysis.
Conference: 15th Annual ENETS conference 2018 (2018)
Category: Basic Science - Genetics, epigenetics, miRNAs, Omics
Presenting Author: Antonio Pea

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