Genomic and Transcriptomic Characterization of Aggressive Well Differentiated Pancreatic Neuroendocrine Tumors (WD PanNET) Abstract #2293

Introduction: While the genomic and transcriptomic landscape of low proliferating PanNET have been well studied, pathways driving aggressive WD PanNET are still unclear.
Aim(s): Study the genomic and transcriptomic characteristics of aggressive WD PanNET
Materials and methods: The transcriptomic profile of 26 WD PanNET (Ki-67<5% n=7, Ki-67 5-15% n=5, Ki-67>15% n=14) and 3 NEC was obtained together with the whole exome sequencing of the 14 aggressive WD PanNET (Ki-67>15%). Pathways activated were confirmed by RPPA and immunohistochemistry.
Conference: 15th Annual ENETS conference 2018 (2018)
Category: Basic Science - Genetics, epigenetics, miRNAs, Omics
Presenting Author: Dr Jerome Cros

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