Genomic and Transcriptomic Characterization of Aggressive Well Differentiated Pancreatic Neuroendocrine Tumors (WD PanNET)

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Introduction: While the genomic and transcriptomic landscape of low proliferating PanNET have been well studied, pathways driving aggressive WD PanNET are still unclear.

Aim(s): Study the genomic and transcriptomic characteristics of aggressive WD PanNET

Materials and methods: The transcriptomic profile of 26 WD PanNET (Ki-67<5% n=7, Ki-67 5-15% n=5, Ki-67>15% n=14) and 3 NEC was obtained together with the whole exome sequencing of the 14 aggressive WD PanNET (Ki-67>15%). Pathways activated were confirmed by RPPA and immunohistochemistry.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Cros J, Soukeur M, Raffenne J, Bernard V, Scoazec J,

Keywords: Exome sequencing, Pancreatic NET, G3 NET,