Targeting Tumor Metabolism in NETs: A Novel Mechanism of Action of the Somatostatin Analog Lanreotide

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Introduction: One of the hallmarks of cancer is reprogramming of energy metabolism, characterized by a shift to aerobic glycolysis. This metabolic switch provides cancer cells appropriate conditions required for enhanced proliferation and survival. The effects of somatostatin on tumor metabolism had not been determined yet.

Aim(s): Study the effects of lanreotide on the metabolic activity of NETs cells.

Materials and methods: BON-1 and NCI-H727 cells were used. Levels of metabolites were determined using 1H-NMR spectrometry. Hexokinase (HK) 2 activity was tested using HK enzymatic assay. Proteins expression and phosphorylation were tested using Western blot. Viability was tested using colony formation assay.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Wolf I

Authors: Wolf I, Hesin A, Rubinstein T, Rubinek T, Shabtay-Orbach A,

Keywords: metabolism, glucose,