Abstract Library

#4390 FDG uptake in lung neuroendocrine tumours and its association with tumour characteristics and prognosis

Introduction: The utility of fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of lung neuroendocrine tumours (L-NETs) remains debated.

Conference:

Presenting Author:

Authors: Twito O, Muzykovskaia E, Frenkel M,

Keywords: lung neuroendocrine tumour, imaging, FDG-PET,

#4387 Exenatide-test for diagnosing endogenous hyperinsulinemic hypoglycaemia: A randomised placebo-controlled cross-over proof-of-principle study – FAST study

Introduction: The gold standard to diagnose endogenous hyperinsulinemic hypoglycaemia (EHH) is the fasting test which is cumbersome and incurs high costs. In the setting of radio-labelled 68Ga-exendin-4 PET/CT in patients with EHH (to localise insulinoma), we unexpectedly observed clinically relevant hypoglycaemia following administration of the tracer, which does usually not occur after GLP-1 agonist therapy in type 2 diabetic patients and in healthy subjects.

Conference:

Presenting Author: Christ E

Authors: Hepprich M, Romberg C, Fricke J, Freitag M, Mudry J,

Keywords: endogenous hyperinsulinemic hypoglycaemia, insulinoma, Exendin, Fasting test,

#4336 Life-threatening hypoglycaemia due to insulinoma successfully treated with PRRT

Introduction: Malignant insulinoma is an uncommon tumour that is usually accompanied by severe hypoglycaemia.

Conference:

Presenting Author:

Authors: Ledwon A, Michalik B, Kropinska A, Paliczka-Cieslik E, Blewaska A,

Keywords: insulinoma, sever hypoglycaemia, PRRT,

#4304 Co-targeting the Endocannabinoid System (ES) and mTOR in NEN potentiates their anti-tumour effect via unique metabolic changes

Introduction: The current treatment of neuroendocrine neoplasms (NEN) has limited efficacy, highlighting the need for novel therapeutic approaches. We have previously shown the potential therapeutic benefit when combining ES blocking with Everolimus (Eve).

Conference:

Presenting Author: Avniel-Polak S

Authors: Avniel-Polak S, Kogot-Levin A, Abramovich I, Agranovich B, Polak D,

Keywords: Neuroendocrine neoplasm, Endocannabinoid system, Everolimus, metabolic Changes, metabolomics,

#4098 A case of functional pancreatic neuroendocrine tumor with hypercalcemia as the main manifestation

Introduction: NEN is a type of rare neoplasm originated from peptidenergic neurons and neuroendocrine cells. Even for functional neuroendocrine tumors, the hormones secreted can be temporally and spatially heterogeneous. Hypercalcemia being a rare clinical manifestation of F-pNEN.

Conference:

Presenting Author: Yingmei T

Authors: Yanping Z, Yingmei T, Jieting D,

Keywords: pancreatic neuroendocrine tumor, functional, parathyroid hormone related peptide,