Abstract Library
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ENETS Abstract Search
Introduction: Neuroendocrine tumors are heterogeneous, often functional malignancies and their therapeutic options are limited. As the PI3 kinase signaling is in GEP-NENs, selective PI3Kalpha inhibitors may be more potent than panPI3K inhibitors.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Grabowski P
Authors: Nölting S, Rentsch J, Freitag H, Briest F, Schrader J,
Keywords: PI3Kalpha, BYL719, neuroendocrine tumor cell lines,
Introduction: Gastroenteropancreatic neuroendocrine neoplasms are fairly rare tumors with very heterogeneous behavior and molecular characteristics. Their generally slow proliferation render them virtually resistant to many DNA damaging therapeutic approaches. Bortezomib has been shown to be effective in GEP-NENs in vitro but has been withdrawn from clinical assessment due to a small phase II study on bortezomib monotherapy in 2004.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Briest F
Authors: Briest F, Christen F, Worpenberg L, Welzel M, Freitag H,
Keywords: GEP-NEN, targeted therapy, DNA repair, chemotherapy,
Introduction: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are heterogeneous in their clinical behavior and therapeutic options are still not satisfactory. The “crosstalk” of different signaling pathways in NEN cells appears to be more complex as known already. PKI-587 is a highly potent novel dual inhibitor of PI3K and mTORC1/C2.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author:
Authors: Freitag H, Briest F, Christen F, Grass I, Lewens F,
Keywords: dual inhibition, PI3K, mTOR, PKI-587,RAD001, signaling,
Introduction: Bronchial neuroendocrine neoplasias comprise a wide spectrum of well-differentiated tumors (typical/atypical carcinoids) to undifferentiated carcinomas such as small (SCLC) and large cell (LC) neuroendocrine carcinomas with a fatal prognosis. Therapeutic options are unsatisfactory.
Conference: 11th Annual ENETSConcerence (2014)
Presenting Author: Lewens F
Authors: Lewens F, Freitag H, Briest F, Heilmann M, Schneider C,
Keywords: bronchial, NETs, PI3K, FoxM1, survivin, cell lines, SCLC,
Introduction: Forkheadbox proteins (Fox proteins) are transcriptions factors. They are highly conserved key players in a large number of cellular processes. Fox proteins have been described as acting as both tumor suppressors and oncogenes. Most notably, they operate in the context of the majority of cancer-related pathways. Information about the fuunction of these proteins in gastroenteropancreatic neuroendocrine neoplasias is scant.
Conference: 11th Annual ENETSConcerence (2014)
Presenting Author: Briest F
Authors: Briest F, Freitag H, Lewens F, Kaemmerer D, Hörsch D,
Keywords: Forkheadbox proteins, signalling network, immunohistochemistry, siRNA, microarray technique,