Abstract Library

#1362 Targeting Tumor Metabolism in NETs: A Novel Mechanism of Action of the Somatostatin Analog Lanreotide

Introduction: One of the hallmarks of cancer is reprogramming of energy metabolism, characterized by a shift to aerobic glycolysis. This metabolic switch provides cancer cells appropriate conditions required for enhanced proliferation and survival. The effects of somatostatin on tumor metabolism had not been determined yet.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Wolf I

Authors: Wolf I, Hesin A, Rubinstein T, Rubinek T, Shabtay-Orbach A,

Keywords: metabolism, glucose,

#640 Chomogranin A, NSE, and 5-Hydroxyindolacetic Acid Measurements in Malignant Carcinoids

Introduction: GEP-NETs are a heterogeneous group of cancers more common in the small intestine which are usually asymptomatic. In patients with malignant carcinoids, a number of tumor markers (TMs) have been considered enclosing urinary 5-hydroxyindolacetic acid (5-HIAA), chromogranin A (CgA), and neuron-specific enolase (NSE) serum levels measurements. Unfortunately, the sensitivity of each TM largely depends on disease extent and the presence of functioning tumors, and thus their usefulness is still unclear.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Lumachi F, Loriggiola L, Marchesini M, Manfè A,

Keywords: malignant carcinoids,