The Association between Gastrin and Glucose Serum Concentration in Hypergastrinemic Patients with Gastric Neuroendocrine Tumors Type 1 and ECL-Cells Hyperplasia

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Introduction: There is previous data demonstrating that elevated gastrin levels could exert some effect potentiating the glucose-induced insulin secretion.

Aim(s): To evaluate whether there is a relation between fasting serum glucose and/or HbA1c and serum gastrin concentrations in patients with ECL-cells hyperplasia (ECH) and gastric neuroendocrine tumors type 1 (G1NETs).

Materials and methods: Gastrin (normal range: <110pg/ml), fasting glucose levels (normal range: 70 to 100mg/dl) and HbA1c (%) were measured in 112 patients with either ECH (n=38) or G1NETs. (n=74). Impaired Fasting Glucose (IFG) was defined as fasting glucose level ≥ 100mg/dl. None of the patients was on medication known to affect gastrin levels.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Mavroeidi V

Authors: Moschouris P, Mavroeidi V, Nikolopoulos G, Tsoli M, Karapanagioti A,

Keywords: Gastric Neuroendocrine Tumors Type 1, ECL-Cells Hyperplasia, gastrin, glucose,