Abstract Library

#856 DAXX and ATRX Loss Defines Chromosomal Instability and Poor Outcome in Pancreatic NET

Introduction: Chromosomal Instability (CIN) has been reported in pancreatic neuroendocrine tumors (pNETs) with poor outcome. However, no specific genetic background has been associated with CIN. Whole exome sequencing revealed mutations in DAXX (Death domain associated protein gene) and ATRX (ATR-X gene) in 40% of pNETs. DAXX and ATRX mutations in pNETs are associated with Alternative Lengthening of Telomeres (ALT) activation.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Marinoni I, Schmitt A, Vassella E, Dettmer M, Rudolph T,

Keywords: pNET, Daxx, Atrx, ALT, CIN,