Abstract Library
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ENETS Abstract Search
Introduction: Extracellular fragments derived from membrane receptors can play relevant functional roles in certain tumoral pathologies and could provide novel diagnostic or therapeutic tools. We have identified a novel truncated somatostatin receptor type 5 variant, sst5TMD4, which is overexpressed and functionally active in different endocrine-related cancers, including neuroendocrine tumors (NETs). Interestingly, sst5TMD4 has 4 transmembrane domains and its C-terminal tail is consequently exposed towards the extracellular matrix, and could, therefore, be the substrate for proteolytic enzymes.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author:
Authors: Pedraza-Arévalo S, Del Río-Moreno M, Alors-Pérez E, Castaño J, Luque R,
Keywords: sst5TMD4, derived peptides, malignancy, endocrine-related cancer,
#1875 Potential Anti-Tumor Activity of Biguanides and Statins in Neuroendocrine Tumor Cells
Introduction: Recent studies have suggested that biguanides and statins have beneficial effects on various cancer types; however, the precise effects and the molecular mechanisms underlying this pathophysiological association are still not well understood in neuroendocrine tumor (NETs).
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Authors: Herrera-Martínez A, Pedraza-Arévalo S, López-López F, Gahete M, Gálvez-Moreno M,
Keywords: NETs,biguanides,statins,
Introduction: Splicing is an emerging cancer hallmark influencing multiple tumor cell (dys)functions. We have shown that aberrantly spliced variants of somatostatin receptor subtype 5 (sst5TMD4) and of the pleiotropic neuropeptide ghrelin (in1ghrelin) are linked to poor prognosis in gastroenteropancreatic neuroendocrine tumors (GEPNETs) and may enhance their aggressiveness features.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Castaño J
Authors: Castaño J, Pedraza-Arevalo S, Herrea-Martinez A, Del Río-Moreno M, Sánchez-Sánchez R,
Keywords: Splicing,
Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are relatively rare and complex neoplasms that present many clinical challenges. High grade at diagnosis is an adverse prognostic factor
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Moreno-Ríos J
Authors: Moreno-Ríos J, Vergara R, Lim M, Castillo-Fernandez O,
Keywords: neuroendocrine tumors, neoplasm, unknown primary, High grade,
Introduction: Gastroenteropancreatic neuroendocrine tumours (GEP-NET) are rare neoplasm with a rising incidence worldwide.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author:
Authors: Castillo-Fernandez O, Vergara R, Moreno-Ríos J, Cukier M, Tapia H,
Keywords: grade, prognosis, neuroendocrine tumor,