Abstract Library

#2995 Prediction of Symptomatic Mesenteric Mass in Patients with Small Intestinal Neuroendocrine Tumors Using a CT Radiomics Approach

Introduction: A mesenteric mass surrounded by fibrosis is a hallmark feature of small intestinal neuroendocrine tumors (SI-NETs) that can induce severe abdominal complications. To improve clinical outcome, there is a need for personalized treatment strategies based on accurate prediction of development of abdominal complications.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Blazevic A

Authors: Blazevic A, Starman M, Brabander T, Hofland J, Franssen G,

Keywords: Small-intestinal neuroendocrine tumors, mesenteric mass, mesenteric fibrosis, radiomics, CT scan,

#1078 Somatostatin Responsive ACTH and Precursor Excess in a Midgut Mesentery NET

Introduction: ACTH production from a midgut mesentery NET is extremely rare (1). A 62y old woman presented with hypokalaemia (2mmol/L) and hyperpigmentation, 11y after surgery of a pT3N1Mx non-functional G1 NET with SRS positive, non-resectable but stable, residual mass encasing mesenteric vessels. Serum cortisol (3261 nmol/L), ACTH (796 ng/L), CgA (530 pmol/L) and urine total cortisol metabolites (33920 µg/24h) including 14 sub-products indicated change of biological behaviour into a functioning NET. Pituitary or pulmonary sources were excluded

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Weickert M, Khan S, Shatwell W, Chambers L, Tomkins C,

Keywords: NET, ACTH precursors, POMC, somatostatin,

#1006 The Use of Endoluminal Stents to Overcome Vascular Obstruction Arising from Mesenteric and Retroperitoneal Neuroendocrine Metastases

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NET) often metastasise to lymph nodes. Nodal metastases from neuroendocrine tumors in the distal small intestine commonly (>50%) develop in the mesentery and are often centred at the mesenteric root surrounding the major vessels supplying the bowel. Compression of these vessels, by the nodes or associated fibrosis, can lead to severe symptoms such as pain (secondary to bowel ischaemia ), ascites (from superior mesenteric vein obstruction) and bowel perforation. In view of the often indolent nature of GEP-NET, symptoms from lymph node masses can persist for years, causing significant morbidity and early mortality.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Anthoney A, Patel J, Kamposioras K,

Keywords: gastroenteropancreatic neuroendocrine tumor, endoluminal stent, mesentery,

#556 Unresectable Mesenteric Midgut NETs: Are They a Unique Prognostic Category?

Introduction: Patients with lymph-node positive midgut NETs (stage IIIB) represent a heterogeneous group. While some have microscopic lymph node involvement on pathological evaluation, others may develop large, desmoplastic, unresectable tumors in the root of the mesentery.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Strosberg J, Weber J, Feldman M, Kvols L,

Keywords: neuroendocrine tumors, carcinoid tumor, midgut, lymph node metastases, stage III,

#424 Role of MicroRNAs in Small Intestine Neuroendocrine Tumors

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) arise from enterochromaffin cells, which belong to the endocrine system. MicroRNAs (miRs) are post-transcriptional regulators. They control multiple biological processes often functioning either as tumor suppressor genes or oncogenes.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Li S, Martijn C, Essaghir A, Lloyd R, Demoulin J,

Keywords: small intestine, neuroendocrine tumors, microRNA profiling ,