Abstract Library

#4356 Assessment of medium- and long-term side effects of Lu-177 treatment in patients with neuroendocrine tumours

Introduction: PRRT with Lu-177 has advanced the treatment of neuroendocrine tumours (NETs), adding a valuable tool against them. This study aims to assess its long-term impact, especially on the most radio-exposed organs—kidneys and bone marrow—and the reproducibility of in vivo clinical trial results (PFS).

Conference:

Presenting Author: Salcedo Cortes S

Authors: Salcedo Cortes S, Ardila Manjarés E, Mari Hualde A, Guzman Cruz A, Casallas Cepeda M,

Keywords: Neuroendocrine tumour (NET), [177Lu]Lu-DOTATATE, Long-term side effects, Radiosensitive organs, PFS,

#3851 68Ga-DOTATOC PET radiomics as a novel preoperative predictive tool for PanNETs aggressiveness

Introduction: The knowledge of Pancreatic Neuroendocrine Tumors (PanNETs) features of aggressiveness before surgery is fundamental for an appropriate treatment planning.

Conference:

Presenting Author:

Authors: Mapelli P, Bezzi C, Ghezzo S, Muffatti F, Andreasi V,

Keywords: 68Ga-DOTATOC, NET, PET, radiomics,

#3317 Digital image analysis of the Ki67 spatial distribution improves classification and grading in gastroenteropancreatic neuroendocrine neoplasms

Introduction: Ki67 is a reliable grading and prognostic biomarker in gastroenteropancreatic neuroendocrine neoplasms (NENs). Intra-tumor heterogeneity of Ki67, correlated with NENs classification, is a valuable factor requiring robust measurement protocols. Digital image analysis enables high accuracy and reproducibility to evaluate the spatial distribution of Ki67.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Huang D

Authors: Huang D, Wang X, Tan C, Sheng W,

Keywords: digital image analysis, Ki67, spatial distribution, NEN, classification, grade,

#3132 Plasmatic and urinary 5-hydroxyindolacetic acid measurements in patients with midgut neuroendocrine tumors: A GTE study

Introduction: Although 24-hour urinary 5-hydroxyindolacetic acid (24u5HIAA) is a key biomarker in midgut NET, it may be inaccurate and inconvenient.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: de Mestier L

Authors: de Mestier L, Savagner F, Brixi H, Do Cao C, Dominguez S,

Keywords: neuroendocrine tumor, carcinoid syndrome, 5-hydroxyindolacetic acid, biomarker, diagnosis,

#2745 Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids

Introduction: Lung carcinoids (LCs) are rare and slow growing primary lung neuroendocrine tumors. The WHO classify LCs into atypical and typical carcinoids. Recent studies have shown that the reproducibility of LCs classification and its prognostic efficacy have high interobserver variability

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Laddha S

Authors: Laddha S, da Silva E, Robzyk K, Untch B, Ke H,

Keywords: MEN1, Lung Carcinoid, Lung Cancer, ASCL1, Novel Molecular Subtypes, Genotype to Phenotype, Integrative Genomic Analysis, Biomarkers, Genomics and Epigenomics,