Abstract Library

#2992 The PanNENomics Project: A Call for an International Collaborative Effort Built on the Success of the LungNENomics Project

Introduction: Neuroendocrine tumors are rare understudied diseases at the molecular level, especially those occurring in sites outside the lung and the gastrointestinal track. This lack of knowledge has strong implications for the clinical management of these diseases (Rindi et al. Mad Pathol 2018).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Fernandez-Cuesta L

Authors: Fernandez-Cuesta L, Foll M, Walter T, Girard N, Lantuejoul S,

Keywords: Rare Cancers genomics, lungNENomics, panNENomics, supra-carcinoids, tumor maps,

#935 A Three Tier Grading System Based on Ki-67 Index, Mitotic Count and Necrosis with Cut-Offs Specifically Generated for Lung Neuroendocrine Tumors is Prognostically Effective and Accurate

Introduction: Lung neuroendocrine tumors are catalogued into four categories by the World Health Organization (WHO 2004) classification. Its reproducibility and prognostic efficacy was disputed. The WHO 2010 classification of digestive neuroendocrine neoplasms is based on a Ki-67 index and has proved prognostically effective.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Rindi G, Klersy C, Inzani F,

Keywords: lung, neuroendocrine cancer, Ki-67, grading,

#756 Evaluation of VEGF, VEGFR 1-2-3 and Endocan/ESM-1 Expression in Gastroenteropancreatic Neuroendocrine Tumors and Correlation with Ki-67 Labeling and Prognosis

Introduction: Angiogenesis is recognized to play a critical role in progressive tumor growth and spreading and its inhibition is a valuable approach to cancer treatment. Markers of angiogenesis include assessment of microvessel density on tissue sections (often evaluated with antibodies against pan-endothelial antigens, such as CD34) and expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR 1-2-3). Endocan, also called endothelial cell specific molecule-1 (ESM-1), has been shown to be expressed by endothelial tumor cells and especially by tip cells during angiogenesis. Endocan is highly up-regulated by pro-angiogenic molecules, such as VEGF. Recently, Endocan has been identified to be one of the molecules involved in the switch from dormant to fast-growing tumors. Among endocrine tumors, Endocan expression has been evaluated only in pituitary adenomas: a positive association between endothelial Endocan expression and recurrence risk, tumor size, tumoral invasion and average mitosis count has been demonstrated. In contrast, there was no association between endothelial Endocan expression and the Ki-67 labeling index

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Lugli F, Iacovazzo D, Fusco A, Lanza P, Rindi G,

Keywords: endocan, angiogenesis, vegf,

#580 Diagnostic Performance of Dual Tracer PET/CT in Staging Neuroendocrine Tumors of the Lung

Introduction: Different positron emission tomography/computed tomography (PET/CT) tracers may be useful in staging lung neuroendocrine tumors (LNETs)

Conference:

Presenting Author:

Authors: Treglia G, Stefanelli A, Cardillo G, Lococo F, Rindi G,

Keywords: Neuroendocrine tumors, lung carcinoids, PET/CT,

#132 Correlation of Ki-67 proliferative index with pathological features and outcome in pancreatic endocrine tumors

Introduction: Information on relationships between Ki-67 values and clinicopathological features in pancreatic endocrine tumors (PETs) is scant and comes mostly from a small series.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Zerbi A, Falconi M, Rindi G, Delle fave G, Tomassetti P,

Keywords: pancreas, endocrine tumor, Ki-67,