Abstract Library
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#1544 Immunohistochemical Expression of Estrogen and Progesterone Receptors in Neuroendocrine Tumors
Introduction: Expression of progesterone (PR) and estrogen receptor (ER) in some neuroendocrine tumors (NET) raises the possibility of hormonal regulation in these tumors, but those prevalence and clinical implication are unknown.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Silva M
Authors: Costa D, Albuquerque C, Boente L, Araujo D, Fares A,
Keywords: progesterone, estrogen, carcinoid,
Introduction: MTC is a rare thyroid malignancy representing approximately 5-10% of all thyroid tumors. Early diagnosis and radical surgery are essential to reduce the morbidity and mortality associated with MTC. Somatostatin receptors (SSTRs) expression has been described in MTC with a variable pattern, SSTR2 being prevalent. Although somatostatin analogues demonstrated poor efficacy in the control of MTC growth, SSTR expression can be useful in Nuclear Medicine diagnostic procedures. 111In-pentetreotide scintigraphy and 68Ga-somatostatin analogues PET-CT represent valuable techniques in the detection of MTC, although with a lower sensitivity compared to 18F-DOPA PET-CT.
Conference: 10th Annual ENETSConcerence (2013)
Presenting Author:
Authors: Iacovazzo D, Piacentini S, Lugli F, Fusco A, Perotti G,
Introduction: Angiogenesis is recognized to play a critical role in progressive tumor growth and spreading and its inhibition is a valuable approach to cancer treatment. Markers of angiogenesis include assessment of microvessel density on tissue sections (often evaluated with antibodies against pan-endothelial antigens, such as CD34) and expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR 1-2-3). Endocan, also called endothelial cell specific molecule-1 (ESM-1), has been shown to be expressed by endothelial tumor cells and especially by tip cells during angiogenesis. Endocan is highly up-regulated by pro-angiogenic molecules, such as VEGF. Recently, Endocan has been identified to be one of the molecules involved in the switch from dormant to fast-growing tumors. Among endocrine tumors, Endocan expression has been evaluated only in pituitary adenomas: a positive association between endothelial Endocan expression and recurrence risk, tumor size, tumoral invasion and average mitosis count has been demonstrated. In contrast, there was no association between endothelial Endocan expression and the Ki-67 labeling index
Conference: 10th Annual ENETSConcerence (2013)
Presenting Author:
Authors: Lugli F, Iacovazzo D, Fusco A, Lanza P, Rindi G,
Keywords: endocan, angiogenesis, vegf,
#547 Insulin Autoimmune Syndrome Mimicking Insulinoma: A Challenging Diagnosis
Introduction: Insulin autoimmune syndrome (IAS) is a rare condition characterized by hypoglycemia due to autoantibodies against endogenous insulin. It is correlated, in approximately 50% of cases, to specific drugs intake. Hypoglycemia occurs typically during the late post-prandial period.
Conference: 9th Annual ENETSConcerence (2012)
Presenting Author:
Authors: Lugli F, Iacovazzo D, Fusco A, Bianchi A, Chiloiro S,
Keywords: autoimmune, insulinoma, hypoglycemia,
Introduction: EUS-FNTA is increasingly used in the diagnosis of pancreatic endocrine tumors (PETs). Ki-67 expression, an important prognostic factor according to the WHO classification, is difficult to be determined on cytological specimens.
Conference: 9th Annual ENETSConcerence (2012)
Presenting Author:
Authors: Larghi A, Fusco A, Bianchi A, Lugli F, Iacovazzo D,