Abstract Library

#2815 Unexpected High Rate of Metastases in Type 1 Gastric Neuroendocrine Neoplasia

Introduction: Gastric neuroendocrine neoplasms (gNEN) represent about 7.5% of gastroenteropancreatic NEN (gepNEN), classified in: type 1 (70-80%), related to autoimmune gastritis, type 2 (5%), related to Zollinger-Ellison syndrome in multiple endocrine neoplasia 1 and type 3 (15-20%), in absence of hypergastrinemia or mucosal atrophy.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Bottiglieri F, Modica R, de Cicco F, Minotta R, Faggiano A,

Keywords: gastric, neuroendocrine, type1, type3, metastases,

#2804 Claudin-18 Is a Sensitive and a Specific Marker for Gastric Neuroendocrine Tumors

Introduction: Antibody-based cancer therapies are emerging as promising therapeutics in oncology, including one in clinical trials that targets claudin-18, a protein expressed in normal gastric epithelium and some gastric adenocarcinoma. We currently have no markers for gastric well-differentiated neuroendocrine tumors (NETs).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Wong M, Huynh C, Kim S, Dhall D, Guindi M,

Keywords: claudin-18, anti-claudin 18, neuroendocrine tumor, neuroendocrine hyperplasia, autoimmune metaplastic atrophic gastritis,

#2125 Subtype Classification and Clinicopathological Features of Gastric Neuroendocrine Neoplasms: 400 Cases of Multicenter Retrospective Analysis

Introduction: Definitions of Type 3 gastric NEN (g-NEN) in ENETS Guidelines 2012 and 2016 are ambiguous and controversial, so Four-type classification has been proposed in China.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Li Y

Authors: Li Y, Zhang P, Qiu X, Li X, Zhang Y,

Keywords: gastric nen, subtype classification,

#1890 Natural History of Type 1 Gastric Carcinoid (gNENs) and Risk of Adenoma/Adenocarcinoma in Endoscopic Surveillance Programme

Introduction: Patients with gNENs & autoimmune gastritis are exposed to 2 malignant risks: 1)transformation of gNENs, felt to be low & guidelines advocate either resection of all lesions or selective endoscopic mucosal resection(EMR) of larger lesions; 2)ill-defined risk of gastric adenoma/adenocarcinoma.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Chin J, O’Connell J, O’Mahony S, Van Boxel O, Muldoon C,

Keywords: Type 1 g-NENs,

#1593 Role of SSA in the Management of Multiple Type 1 Gastric Neuroendocrine Neoplasms

Introduction: Type 1 g-NENs associated with autoimmune chronic atrophic gastritis have high risk of recurrence but rare metastasis. Most type 1 patients are managed by endoscopic approach. The clinical benefit of somatostatin analogues (SSA) for type 1 g-NENs is controversial.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Tan H

Authors: Li Y, Dou D, Tan H,

Keywords: SSA, gastric nen, type 1,