#3056
Multi-Omic Characterization and Evolution of Neuroendocrine Neoplasm Organoids
Introduction:
Molecular characterizations of neuroendocrine neoplasm (NENs) have unveiled candidate alterations associated with aggressiveness and suggested that the molecular link between neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) might be subtler than initially thought. For example, we have recently unveiled a new entity of pulmonary carcinoids (supra-carcinoids) with carcinoid-like morphology yet the molecular and clinical features of large cell neuroendocrine carcinoma (LCNEC). Testing hypotheses to explain aggressiveness and the possibility of progression or transition from NET to NEC through the accumulation of genetic anomalies requires in vitro and in vivo experimental models.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Foll M
Authors:
Alcala N,
Dayton T,
Mangiante L,
Delhomme T,
Tabone-Egling S,
Keywords:
organoids,
omics,
evolution,
lung,
pancreas,
bioinformatics,
#2781
Case Report: Whole Exon Sequencing of Primary Lesion and Metastatic Liver Lesion in Pancreatic Neuroendocrine Tumor
Introduction:
Pancreatic neuroendocrine neoplasms(NENs) are classified into neuroendocrine tumors (NET) G1, G2, G3, and neuroendocrine carcinoma (NEC), which are different pathogenesis. The two kinds of tumors that occurs in the same lesion in one patient is very rare. We found high grade neuroendocrine neoplasms(NENG3) with a diameter of 0.1 cm in a patient with a pancreatic NETG2 (1.7 cm in diameter). The cells were significant atypia with Ki67 index of 60%, focal necrosis, while metastatic nodules in the liver (12, 0.1-1.1 cm in diameter) were all high grade NENG3.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Authors:
Shi Y,
Zhong D,
Li Y,
Niu Y,
Tan H,
Keywords:
pancreatic neuroendocrine neoplasms,
whole exon sequencing,
TRIOBP signaling pathway,
MDM4,
#658
Somatic Mutations in H-RAS in Sporadic Pheochromocytoma and Paraganglioma Identified by Exome Sequencing.
Introduction:
Up to 60% of pheochromocytoma (PCC) and paraganglioma (PGL) are associated with mutations in established PCC and PGL susceptibility loci. A majority of unexplained cases are characterized by an increased activity of the RAS/RAF/ERK signalling pathway. Mutations in RAS subtypes H, K and N are common in human cancers, however, previous studies have been inconsistent regarding the mutational status of RAS in PCC and PGL.
Conference:
10th Annual ENETSConcerence (2013)
Presenting Author:
Authors:
Crona J,
Delgado Verdugo A,
Stålberg P,
Granberg D,
Hellman P,
Keywords:
H-RAS,
pheochromocytoma,