Exploring the interplay between chromatin-remodeling genes and the regulation of alternative splicing and RNA biology in lung neuroendocrine neoplasms

#3568

Introduction: Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of rare tumors, but with a rising incidence in the last decades. The mutational landscape of LungNENs has been recently described; in contrast, other key regulatory mechanisms, particularly posttranscriptional processes linked to RNA regulation, remain largely unexplored.

Aim(s): Here, we aimed to investigate the role of genes involved in chromatin-remodeling regulation, focusing on their mutations and their interplay with RNA processing in LungNENs.

Materials and methods: To this end, we analysed RNA-seq data from two cohorts: 1) 20 lung atypical carcinoids, and 2) 30 typical/atypical carcinoids. We applied a biocomputational approach to interrogate the potential influence of the dysregulation of the selected genes. Additionally, we explored the potential associations between the mutated genes and other factors contributing to RNA processing.

Conference:

Presenting Author: Agraz-Doblas A

Authors: Agraz-Doblas A, Blázquez-Encinas R, Victor G, Alcala N, Sexton-Oates A,

Keywords: Lung NEN, Bioinformatics, Chromatin-remodeling, RNA, biomarker, mutations,