Abstract Library

#4152 Valvular surgery in carcinoid heart disease – Indications and outcome

Introduction: Neuroendocrine tumors (NET) can release biogenic amines that can induce a fibrotic process in the heart valves known as carcinoid heart disease (CHD). Valvular replacement surgery is the standard of care, but such interventions are associated with significant morbidity and valid criteria for both selecting patients (pts) and timing of surgery are limited.

Conference:

Presenting Author:

Authors: Sponheim J, Beitnes J, Dahle G, Åvitsland T, Thiis-Evensen E,

Keywords: carcinoid heart disease, valvular surgery, prognostic factors,

#3994 Outlook for 615 small intestinal neuroendocrine tumor patients: Recurrence risk after surgery and disease-specific survival in advanced disease

Introduction: Small intestinal neuroendocrine tumors (siNET) are one of the most common neuroendocrine neoplasms. Radical surgery is the only curative treatment.

Conference:

Presenting Author: Andreassen M

Authors: Slott C, Langer S, Møller S, Krogh J, Klose M,

Keywords: Small intestinal neuroendocrine tumor survival, prognosis, recurrence,

#3966 PTK2 PROTAC unveiled as a selective inhibitor of gastrointestinal neuroendocrine cell proliferation via multi-target drug screening

Introduction: Gastrointestinal neuroendocrine tumors (GI-NETs) exhibit a complex and diverse nature, posing challenges in their effective treatment and management. While there have been advancements in treatment options, addressing the need for more effective and targeted therapies remains a significant issue, especially for patients with advanced or metastatic disease. Improving outcomes in the management of patients with GI-NETs is a key priority, and further research and development are crucial in this regard.

Conference:

Presenting Author: Gagliano T

Authors: Malavasi E, Toffoli L, Dainotto M, Gagliano T,

Keywords: Protac, PTK2, Screening, GI-NETs,

#3667 Outcome of endoscopic submucosal dissection for rectal neuroendocrine neoplasms – A multicentre study

Introduction: Recent guidelines recommend advanced endoscopic resection techniques, such as Endoscopic Submucosal Dissection (ESD), for the treatment of rectal neuroendocrine neoplasms (R-NENs) under 15mm due to high rate of positive margins at Endoscopic Mucosal Resection (EMR).

Conference:

Presenting Author: Rimondi A

Authors: Rimondi A, Despott E, Lemmers A, Chacchi-Cahuin R, Lazaridis N,

Keywords: ESD, R-NENs, endoscopy,

#3331 Outcomes of upfront treatment with mFOLFIRINOX regimen in G3 GEP-NENs: A monocentric retrospective experience

Introduction: To date outcomes of standard chemotherapy are not homogeneous in different subgroups of G3 GEP-NENs and remain unsatisfactory and poor; new therapeutic options are desirable in this setting.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Borghesani M

Authors: Borghesani M, Reni A, Zaninotto E, Fumagalli A, Benini L,

Keywords: net, mfolfirinox, chemotherapy, g3, minen,