#3056
Multi-Omic Characterization and Evolution of Neuroendocrine Neoplasm Organoids
Introduction:
Molecular characterizations of neuroendocrine neoplasm (NENs) have unveiled candidate alterations associated with aggressiveness and suggested that the molecular link between neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) might be subtler than initially thought. For example, we have recently unveiled a new entity of pulmonary carcinoids (supra-carcinoids) with carcinoid-like morphology yet the molecular and clinical features of large cell neuroendocrine carcinoma (LCNEC). Testing hypotheses to explain aggressiveness and the possibility of progression or transition from NET to NEC through the accumulation of genetic anomalies requires in vitro and in vivo experimental models.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Foll M
Authors:
Alcala N,
Dayton T,
Mangiante L,
Delhomme T,
Tabone-Egling S,
Keywords:
organoids,
omics,
evolution,
lung,
pancreas,
bioinformatics,
#3041
Resource Use in Patients with Carcinoid Syndrome: A Retrospective Analysis Using the French Health Insurance National (SNDS) Database
Introduction:
About 20% of patients (pts) with neuroendocrine tumors (NET) suffer from carcinoid syndrome (CS), mainly from ileum and lung NET. Pts with CS experience symptoms such as diarrhea, flushes and cardiac complications. The diarrhea occurs in almost all pts with CS and can be truly debilitating. Therefore, on top of the tumor, the burden of the symptoms further impairs quality of life and is associated with additional costs related to symptom management and pts follow-up.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Walter T
Authors:
Walter T,
Lapeyre Mestre M,
Gueguen D,
Bouille C,
Laborey M,
Keywords:
Carcinoid syndrome,
resources,
health economics,
#3036
Can Ki-67 with 5.5% Be Better in Predicting Prognosis for Well Differentiated Pancreatic Neuroendocrine Tumors?
Introduction:
Pancreatic neuroendocrine tumors (NETs) are rare malignancies, Ki-67 is a cell proliferation marker that has been shown to have some utility in predicting prognosis of neuroendocrine tumors. However, the ideal grading method for G1/G2 remains controversial.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Tan H
Authors:
Yuan B,
Chen Y,
Zhang P,
Wang X,
Tan H,
Keywords:
Pancreatic net,
G1,
G2,
Ki-67,
overall survival time,