Abstract Library

#3796 The effect of pseudohypoxia on the immune microenvironment of pancreatic neuroendocrine neoplasms (PanNEN)

Introduction: Pancreatic neuroendocrine tumors may develop sporadically or as part of an inherited disease, such as von Hippel-Lindau (VHL). VHL disease is caused by a germline pathogenic variant in the VHL gene encoding VHL protein (pVHL). Hypoxia inducible factor (HIF) is responsible for cellular oxygen supply. Its degradation is mediated in normoxic states via ubiquitination and inhibited by pVHL. Hence, pVHL deficiency leads to pseudohypoxia due to HIF overexpression. Several studies suggested immunomodulatory role for HIF in kidney cancer.

Conference:

Presenting Author:

Authors: Solomon Chmelnik A, Telerman A, Tirosh A,

Keywords: Pancreatic neuroendocrine tumor, VHL, DNA methylation, Immune cells, PD-L1,

#3146 Transcriptomic deconvolution of neuroendocrine neoplasms predicts clinically relevant characteristics

Introduction: Therapeutic decisions in oncology depend on a precise pathological classification of individual neoplasms. However, a comprehensive training of machine-learning models requires sufficiently large numbers of training samples, which are usually not available for rare cancer types.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Otto R

Authors: Otto R, Detjen K, Riemer P, Grötzinger C, Rindi G,

Keywords: bioinformatics, NET, PanNEN, deconvolution, transcriptomics, RNA-seq, neuroendocrine cancer,