Metachronous Functioning Syndromes in Sporadic Pancreatic Neuroendocrine Tumors (PNET)

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Introduction: A metachronous functioning syndrome (MFS) may develop during the evolution of PNET initially functioning or not.

Aim(s): To describe a multicenter series of MFS occurring in sporadic PNET patients.

Materials and methods: Patients in whom symptoms related to hypersecretion of insulin, gastrin, VIP or glucagon secondary occurred during follow-up were included. A central review of pathological material was performed, including Ki-67 and peptide immunostaining.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: de Mestier L

Authors: De Mestier L, Hentic O, Cros J, Brixi H, Walter T,

Keywords: neuroendocrine tumors, pancreas, functioning syndrome, natural evolution,