Abstract Library

#4079 Temporal increase in Ki-67 index in patients with pancreatic neuroendocrine tumors (PanNETs): Frequency, prognostic impact, and causal factors

Introduction: PanNETs show intra-tumor heterogeneity, notably regarding Ki-67 index which is a major prognostic biomarker. Temporal heterogeneity and its prognostic impact have been poorly explored so far.

Conference:

Presenting Author: Bourdeleau-Guerry P

Authors: Bourdeleau-Guerry P, Pokossy-Epée J, Hentic O, Couvelard A, Ruszniewski P,

Keywords: neuroendocrine tumor, Ki-67 index, tumor grade, temporal evolution, molecular evolution, biologic evolution,

#4028 Clinical application of digital pathology: Proposal of a new G0 category useful in small intestinal NET (SI-NET)

Introduction: SI-NET display low proliferation rate despite a high frequency of metastases. Ki67 index is frequently reported as “

Conference:

Presenting Author: Couvelard A

Authors: Guedj N, Cléry G, Chassac A, Hentic O, Colnot N,

Keywords: Small Intestinal NET-, grade, survival, prognosis, G1,

#3954 Comparison of transarterial embolisation (TAE) or chemoembolisation (TACE) using streptozotocin (STZ) and biomarker study in patients with metastatic neuroendocrine tumors (NET)

Introduction: We compared TACE and TAE in patients with pancreatic (pNET) or small-intestine NET (siNET) and explored the role of biomarkers related to alkylating agents (O6-methylguanine-methyltransferase [MGMT], alkylpurine–DNA–N-glycosylase [APNG]) or hypoxia (Carbonic anhydrase IX [CAIX]).

Conference:

Presenting Author: de Mestier L

Authors: Vedie A, Dioguardii Burgioo M, Matteini F, Akez M, Hentic O,

Keywords: transarterial embolization, chemoembolization, metastatic neuroendocrine tumor, biomarker,

#3627 Early prediction of the efficacy of 177Lu-DOTATATE in patients with metastatic neuroendocrine tumors

Introduction: PRRT has a major place in the therapeutic strategy of metastatic NETs. Its efficacy is generally evaluated after four cycles, with no early predictor identified to date. During each PRRT cycle, 177Lu-related gamma emissions can be measured by post-PRRT scintigraphy.

Conference:

Presenting Author:

Authors: Bando-Delaunay A, de Rycke O, Hentic O, Leclerc P, Allouch A,

Keywords: PRRT, scintigraphy, prediction, response,

#3427 Updated morphological and immunohistochemical profile of neuroendocrine tumors developed in ovarian teratomas: A large series of a rare disease

Introduction: Ovarian carcinoid tumors are rare, often arising within a mature teratoma. No recent reevaluation of the immunophenotype of these tumors with new markers available has been performed.

Conference:

Presenting Author: Couvelard A

Authors: Leclerc J, Genestie C, Hentic O, Scoazec J, Couvelard A,

Keywords: NET, carcinoid, Ki67, ovarian teratoma, gynecology, pathology,