Temporal increase in Ki-67 index in patients with pancreatic neuroendocrine tumors (PanNETs): Frequency, prognostic impact, and causal factors

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Introduction: PanNETs show intra-tumor heterogeneity, notably regarding Ki-67 index which is a major prognostic biomarker. Temporal heterogeneity and its prognostic impact have been poorly explored so far.

Aim(s): We aimed to describe the temporal evolution of grade and Ki-67 in patients with PanNET, and to explore its favouring factors and prognostic impact.

Materials and methods: We retrospectively studied 109 patients with sporadic PanNETs and serial tumor samples over time (n=286) treated in one expert institution (1993-2021). PanNET morphology and Ki-67 were centrally re-assessed on each sample. Prognostic factors (overall survival) and factors associated with Ki-67 increase were explored using multivariable Cox proportional hazard models or logistic regression models, respectively.

Conference:

Presenting Author: Bourdeleau-Guerry P

Authors: Bourdeleau-Guerry P, Pokossy-Epée J, Hentic O, Couvelard A, Ruszniewski P,

Keywords: neuroendocrine tumor, Ki-67 index, tumor grade, temporal evolution, molecular evolution, biologic evolution,