Abstract Library

#4079 Temporal increase in Ki-67 index in patients with pancreatic neuroendocrine tumors (PanNETs): Frequency, prognostic impact, and causal factors

Introduction: PanNETs show intra-tumor heterogeneity, notably regarding Ki-67 index which is a major prognostic biomarker. Temporal heterogeneity and its prognostic impact have been poorly explored so far.

Conference:

Presenting Author: Bourdeleau-Guerry P

Authors: Bourdeleau-Guerry P, Pokossy-Epée J, Hentic O, Couvelard A, Ruszniewski P,

Keywords: neuroendocrine tumor, Ki-67 index, tumor grade, temporal evolution, molecular evolution, biologic evolution,

#4028 Clinical application of digital pathology: Proposal of a new G0 category useful in small intestinal NET (SI-NET)

Introduction: SI-NET display low proliferation rate despite a high frequency of metastases. Ki67 index is frequently reported as “

Conference:

Presenting Author: Couvelard A

Authors: Guedj N, Cléry G, Chassac A, Hentic O, Colnot N,

Keywords: Small Intestinal NET-, grade, survival, prognosis, G1,

#3790 Pancreatic neuroendocrine tumors (pNETs) in French VHL mutation carriers – A nationwide retrospective study with genotype-phenotype correlations

Introduction: Von Hippel-Lindau disease (VHL) is a rare inheritable syndrome predisposing to pancreatic neuroendocrine tumors (pNETs). The natural history of VHL-related pNETs is ill-known.

Conference:

Presenting Author:

Authors: Muller M, Hammel P, Sauvanet A, Couvelard A, Vullierme M,

Keywords: hereditary neoplastic syndrome, von Hippel-Lindau disease, VHL gene, pancreatic neuroendocrine tumor,

#3712 Germline pathogenic variants in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms

Introduction: High-grade gastroenteropancreatic (HG-GEP) neuroendocrine neoplasms (NEN) are aggressive cancers with a dismal prognosis. The molecular etiology remains poorly characterized and prevalence of pathogenic germline variants unknown.

Conference:

Presenting Author: Sorbye H

Authors: Sorbye H, Venizelos A, Perren A, Couvelard A, Hjortland G,

Keywords: germline, mutations, gastropancreatic, neuroendocrine carcinoma, NET G3, high-grade,

#3486 Treatment response and survival according to molecular alterations in 229 patients with high-grade gastroenteropancreatic neuroendocrine neoplasms (HG GEP-NEN)

Introduction: HG GEP-NEN consist of well-differentiated neuroendocrine tumors (NET G3) and poorly differentiated neuroendocrine carcinoma (NEC). The majority have advanced disease, limited treatment options and a poor prognosis.

Conference:

Presenting Author: Elvebakken H

Authors: Elvebakken H, Venizelos A, Perren A, Couvelard A, Lothe I,

Keywords: neuroendocrine neoplasm, neuroendocrine carcinoma, high-grade, gastroenteropancreatic, molecular alteration, molecular marker,