Updated morphological and immunohistochemical profile of neuroendocrine tumors developed in ovarian teratomas: A large series of a rare disease

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Introduction: Ovarian carcinoid tumors are rare, often arising within a mature teratoma. No recent reevaluation of the immunophenotype of these tumors with new markers available has been performed.

Aim(s): The objectives of this study were to describe the morphological and immunohistochemical characteristics of neuroendocrine tumors (NETs) arising from ovarian teratomas, to correlate them with the type of teratomatous epithelial components present and to evaluate their proliferative capacities using the WHO recommendations for gastroenteropancreatic NETs.

Materials and methods: This is a bi-centric retrospective study using a large panel of differentiation markers (chromogranins A and B, synaptophysin, CDX2, SATB2, TTF1, PAX8, Serotonin and Calcitonin). Ki-67 proliferation index was determined by image analysis.

Conference:

Presenting Author: Couvelard A

Authors: Leclerc J, Genestie C, Hentic O, Scoazec J, Couvelard A,

Keywords: NET, carcinoid, Ki67, ovarian teratoma, gynecology, pathology,