miRNA Expression Defines Novel Subgroups of Small Intestinal Neuroendocrine Tumors Abstract #2086

Introduction: Epigenetic dysregulation frequently occurs in cancers. Here we present the largest survival related miRNA profiling study to date of small intestinal neuroendocrine tumors (SI-NETs).
Aim(s): The aim of this study was to define novel subgroups of SI-NETs.
Materials and methods: miRNA profiling by microarray analysis was conducted on 42 SI-NETs with known chromosomal alterations, gene expression profile and long-term follow-up. To verify the miRNA profiling, a tissue microarray (TMA) containing 845 biopsies of SI-NETs was used for in situ hybridization of miR-375 as well as for immunohistochemical staining of B-catenin.
Conference: 15th Annual ENETS conference (2018)
Category: Basic Science - Genetics, epigenetics, miRNAs, Omics
Presenting Author: PhD Yvonne Arvidsson

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