miRNA Expression Defines Novel Subgroups of Small Intestinal Neuroendocrine Tumors

#2086

Introduction: Epigenetic dysregulation frequently occurs in cancers. Here we present the largest survival related miRNA profiling study to date of small intestinal neuroendocrine tumors (SI-NETs).

Aim(s): The aim of this study was to define novel subgroups of SI-NETs.

Materials and methods: miRNA profiling by microarray analysis was conducted on 42 SI-NETs with known chromosomal alterations, gene expression profile and long-term follow-up. To verify the miRNA profiling, a tissue microarray (TMA) containing 845 biopsies of SI-NETs was used for in situ hybridization of miR-375 as well as for immunohistochemical staining of B-catenin.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Arvidsson Y, Rehammar A, Bergström A, Andersson E, Altiparmak G,

Keywords: neuroendocrine tumor, small intestine, miRNA, profiling, cluster analysis, survival, miR-375, B-catenin,