Abstract Library

#2196 The Neuroendocrine Phenotype, Genomic Profile, and Therapeutic Sensitivity of GEPNET Cell Lines

Introduction: Patient tumour-derived cell lines have been widely used for studying the molecular mechanisms of tumours and their response to therapy. The establishment of cell lines from gastro-entero-pancreatic neuroendocrine tumours (GEPNETs) has proved difficult, but despite the challenges a limited amount of cell lines now exists.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Hofving T, Arvidsson Y, Almobarak B, Inge L, Pfragner R,

Keywords: neuroendocrine tumor, GEP-NET, immunophenotyping, copy-number alterations, exome sequencing, inhibitor screening, vorinostat, trametinib,

#2086 miRNA Expression Defines Novel Subgroups of Small Intestinal Neuroendocrine Tumors

Introduction: Epigenetic dysregulation frequently occurs in cancers. Here we present the largest survival related miRNA profiling study to date of small intestinal neuroendocrine tumors (SI-NETs).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Arvidsson Y, Rehammar A, Bergström A, Andersson E, Altiparmak G,

Keywords: neuroendocrine tumor, small intestine, miRNA, profiling, cluster analysis, survival, miR-375, B-catenin,

#119 Valproic acid induces apoptosis-mediated cell death of the ileal carcinoid cell line GOT1

Introduction: Downregulation of tumor suppressor genes, evasion from apoptosis, and reduced differentiation are hallmarks of cancer that can be due to abnormal epigenetic control. Histone deacetylase (HDAC) is an enzyme involved in the deacetylation of histone proteins, resulting in chromatin remodelling and altered gene transcription. HDAC inhibitors are emerging as useful anticancer drugs.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Arvidsson Y, Ahlman H, Nilsson O,

Keywords: carcinoid, HDAC, apoptosis, valproic acid,