Abstract Library

#2196 The Neuroendocrine Phenotype, Genomic Profile, and Therapeutic Sensitivity of GEPNET Cell Lines

Introduction: Patient tumour-derived cell lines have been widely used for studying the molecular mechanisms of tumours and their response to therapy. The establishment of cell lines from gastro-entero-pancreatic neuroendocrine tumours (GEPNETs) has proved difficult, but despite the challenges a limited amount of cell lines now exists.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Hofving T, Arvidsson Y, Almobarak B, Inge L, Pfragner R,

Keywords: neuroendocrine tumor, GEP-NET, immunophenotyping, copy-number alterations, exome sequencing, inhibitor screening, vorinostat, trametinib,

#1579 Establishment and Characterization of a Continuous Cell Line from a Human Familial Medullary Thyroid Carcinoma

Introduction: introduction missing

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Pfragner R, Schwach G, Ghaffari Tabrizi-Wizsy N, Hoeger H, Tam-Amersdorfer C,

Keywords: Familial MTC, continuous cell line, characterisation, authentication, xenografts,

#1560 Cannabinoids as Inhibitor of Tumour Growth and Invasiveness in Small Intestine Neuroendocrine Cancer

Introduction: Tumour cell invasion and proliferation is a key factor for the prognosis and progression of cancer. A recent study revealed that cannabinoids can inhibit tumour invasion and proliferation in breast cancer through the down-regulation of ID-1, an inhibitor of helix-turn-helix transcription factors.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Errampalli R

Authors: Errampalli R, Reicher A, Kleinegger F, Hirschnöck T, Pfragner R,

Keywords: si-net, id1, cannabinoid​,

#1182 Epirubicin Loaded Polyphosphazene; A New Agent Against Small Intestinal Neuroendocrine Tumors and Medullary Thyroid Carcinomas

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) represent a group of rare neoplasms, derived mainly from enterochromaffine cells. Medullary thyroid carcinoma (MTC) is a calcitonin-producing neuroendocrine tumor arising from the parafollicular C-cells. SI-NETs as well as MTCs are known for their poor response to standard therapy. Therefore, there is a substantial need to establish new therapeutic options in the clinical treatment of these tumors.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Schwach G, Pfragner R, Hoeger H, Schoefberger W, Wilfert S,

Keywords: epirubicin, polyphosphazene, neuroendocrine tumor,

#1180 A Novel Human Cell Line from Familial Medullary Thyroid Carcinoma

Introduction: Cell lines from hereditary medullary thyroid carcinomas (MTC) are very rare, therefore, there is a substantial need to establish new cell lines. Here, we present a novel familial MTC (FMTC) cell line, designated SCHWE.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Pfragner R, Schwach G, Hoeger H, Ghaffari Tabrizi-Wizsy N, Tam Amersdorfer C,

Keywords: novel MTC cell line, familial MTC, xenografts,