Abstract Library

#1579 Establishment and Characterization of a Continuous Cell Line from a Human Familial Medullary Thyroid Carcinoma

Introduction: introduction missing

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Pfragner R, Schwach G, Ghaffari Tabrizi-Wizsy N, Hoeger H, Tam-Amersdorfer C,

Keywords: Familial MTC, continuous cell line, characterisation, authentication, xenografts,

#1528 Medullary Thyroid Carcinoma Cell Lines – An Update

Introduction: Medullary Thyroid Carcinoma (MTC) originates from calcitonin-producing neuroendocrine C-cells of the thyroid gland. Mutations in the RET-proto-oncogene are associated with both sporadic and familial MTC. As MTC are poorly responsive to chemo- and radiation- therapy, surgery is the only curative treatment at the moment. The cytogenetics of MTC have been sparsely investigated because the cells are very difficult to cultivate. In the last three decades our research group has established 10 continues cell lines derived from primary tumor and lymph node metastasis of patients with either sporadic or hereditary MTC.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Schwach G

Authors: Schwach G, Ghaffari-Tabrizi Wizsy N, Tam-Amersdorfer C, Meier-Allard N, Siddiqui Z,

Keywords: MTC continuous cell line, characterisation, xenografts,

#1182 Epirubicin Loaded Polyphosphazene; A New Agent Against Small Intestinal Neuroendocrine Tumors and Medullary Thyroid Carcinomas

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) represent a group of rare neoplasms, derived mainly from enterochromaffine cells. Medullary thyroid carcinoma (MTC) is a calcitonin-producing neuroendocrine tumor arising from the parafollicular C-cells. SI-NETs as well as MTCs are known for their poor response to standard therapy. Therefore, there is a substantial need to establish new therapeutic options in the clinical treatment of these tumors.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Schwach G, Pfragner R, Hoeger H, Schoefberger W, Wilfert S,

Keywords: epirubicin, polyphosphazene, neuroendocrine tumor,

#1180 A Novel Human Cell Line from Familial Medullary Thyroid Carcinoma

Introduction: Cell lines from hereditary medullary thyroid carcinomas (MTC) are very rare, therefore, there is a substantial need to establish new cell lines. Here, we present a novel familial MTC (FMTC) cell line, designated SCHWE.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Pfragner R, Schwach G, Hoeger H, Ghaffari Tabrizi-Wizsy N, Tam Amersdorfer C,

Keywords: novel MTC cell line, familial MTC, xenografts,