Abstract Library

#2908 Re-Cellularised Human Pancreas 3D Scaffolds as a Novel Model for Biomarker Discovery in Pancreatic Neuroendocrine Tumours (pNETs)

Introduction: The lack of preclinical models of pNETs has challenged identification of tissue specific biomarkers of disease. Culturing cancer cells in their native tissue enables the close study of cell-ECM interaction and tissue remodelling. The biological products of such interactions can form a basis for discovery of novel biomarkers of the disease, and were previously linked with a range of inflammatory and malignant conditions.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Ney A

Authors: Ney A, Al-Akkad W, Frenguelli L, Acedo P, Mazza G,

Keywords: 3d models, pancreatic neuroendocrine tumors, Biomarkers,

#2246 Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH): Characterisation of Prevalence and Prognosis in the Pulmonary Carcinoid Population

Introduction: DIPNECH is considered a rare condition and the natural history is poorly described. It is thought to give rise to pulmonary carcinoids (PCs) (>5mm) or tumourlets (≤5mm).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Hayes A

Authors: Hayes A, Banks J, Shah H, Luong T, Navalkissoor S,

Keywords: dipnech, diffuse idiopathic neuroendocrine cell hyperplasia, tumourlet, carcinoid, neuroendocrine tumor, multiple pulmonary nodules,

#1704 Diffusion Weighted Imaging as a Screening Tool in the Detection and Monitoring of Pancreatic Neuroendocrine Tumours in Patients with Familial Cancer Syndromes.

Introduction: Pancreatic neuroendocrine tumours (PNETs) occur at a higher frequency and at a younger age in patients with certain genetic conditions e.g. Von Hippel Lindau and Multiple Endocrine Neoplasia type 1. Screening for early detection and monitoring growth rates of PNETs in these high risk patients is vital in their management. MRI has emerged as the gold standard for imaging the pancreas for the detection of PNETs and diffusion weighted imaging (DWI) has become an invaluable adjunct.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Jenkins C, Thomas W, Parry C, Khan M, Owen R,

Keywords: PNET, MRI, VHL, MEN1,

#1579 Establishment and Characterization of a Continuous Cell Line from a Human Familial Medullary Thyroid Carcinoma

Introduction: introduction missing

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Pfragner R, Schwach G, Ghaffari Tabrizi-Wizsy N, Hoeger H, Tam-Amersdorfer C,

Keywords: Familial MTC, continuous cell line, characterisation, authentication, xenografts,

#1528 Medullary Thyroid Carcinoma Cell Lines – An Update

Introduction: Medullary Thyroid Carcinoma (MTC) originates from calcitonin-producing neuroendocrine C-cells of the thyroid gland. Mutations in the RET-proto-oncogene are associated with both sporadic and familial MTC. As MTC are poorly responsive to chemo- and radiation- therapy, surgery is the only curative treatment at the moment. The cytogenetics of MTC have been sparsely investigated because the cells are very difficult to cultivate. In the last three decades our research group has established 10 continues cell lines derived from primary tumor and lymph node metastasis of patients with either sporadic or hereditary MTC.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Schwach G

Authors: Schwach G, Ghaffari-Tabrizi Wizsy N, Tam-Amersdorfer C, Meier-Allard N, Siddiqui Z,

Keywords: MTC continuous cell line, characterisation, xenografts,