Clinical characterisation of patients with familial midgut neuroendocrine tumours (FM-NETs) based on a comparison with the large population-based GTE/RENATEN cohort

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Introduction: The clinical specificities of FM-NET have been poorly described.

Aim(s): We aimed to compare the clinical and pathological features of FM-NET with those of sporadic midgut NET, using a large population-based cohort.

Materials and methods: The TCF nationwide ambispective cohort included all patients with FM-NET (histologically proven midgut NET in ≥ 2 first-degree relatives) managed in the French GTE/RENATEN network. Clinical and pathological data were compared to the nationwide population-based GTE/RENATEN cohort which includes 4946 patients with sporadic midgut NET (SM-NET) (of whom 2460 patients were excluded for missing data). Characteristics associated with FM-NET and survival were explored with multivariate logistic regression or Cox proportional hazard models, respectively.

Conference:

Presenting Author: Hunaut T

Authors: Hunaut T, Hercent A, Walter T, Buecher B, Lepage C,

Keywords: Small intestine neuroendocrine tumour, Familial carcinoid tumour,