Abstract Library

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ENETS Abstract Search

#1637 The Effect of the Autophagy Inhibitor Chloroquine (CQ), Alone or in Combination with mTOR Inhibitors, on Neuroendocrine Tumor (NET) Growth and Metastatic Spread in Mouse Models

Introduction: mTOR inhibitors (mTORi) such as RAD001 demonstrated promising anti-cancer effect in NETs. Autophagy, a cell survival mechanism, is activated by mTORi. We have recently shown in the human NET cell line BON1 that autophagy is essential for cell survival. Treatment with CQ alone or together with mTORi robustly inhibited cell proliferation and survival, suggesting that treatment with CQ may potentiate the anti-tumorigenic effects of mTORi.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Avniel-Polak S

Authors: Avniel-Polak S, Leibowitz G, Gross D, Grozinsky-Glasberg S,

Keywords: autophagy, mTORi, NET,

#1528 Medullary Thyroid Carcinoma Cell Lines – An Update

Introduction: Medullary Thyroid Carcinoma (MTC) originates from calcitonin-producing neuroendocrine C-cells of the thyroid gland. Mutations in the RET-proto-oncogene are associated with both sporadic and familial MTC. As MTC are poorly responsive to chemo- and radiation- therapy, surgery is the only curative treatment at the moment. The cytogenetics of MTC have been sparsely investigated because the cells are very difficult to cultivate. In the last three decades our research group has established 10 continues cell lines derived from primary tumor and lymph node metastasis of patients with either sporadic or hereditary MTC.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Schwach G

Authors: Schwach G, Ghaffari-Tabrizi Wizsy N, Tam-Amersdorfer C, Meier-Allard N, Siddiqui Z,

Keywords: MTC continuous cell line, characterisation, xenografts,

#1501 Inhibition of Intestinal Neuroendocrine Tumor by a New Marker of Normal Neuroendocrine Cells

Introduction: Although gastrointestinal neuroendocrine tumors are increasing worldwidely, few treatment options could be chosen

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Guo Y

Authors: Pan B, Yang W, Zhang T, Guo Y,

Keywords: GEP-NETs, Wnt, marker,

#1321 Iodinated Exendin-4 Shows Improved Pharmacokinetic in Rat Insulinoma Model

Introduction: GLP-1 receptor is an important marker for imaging benign insulinomas.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Läppchen T, Tönnesmann R, Meyer P, Maecke H, Rylova S,

Keywords: GLP-1, insulinoma,